The NIH R01 proposal was discussed. Dr. Diller, Dr. Hazle, and Dr. Stafford have been conversing over adding cell permeability as an indicator of cell viability to the next proposal. The January 24th deadline for the NIH proposal is unfeasible. The DDDAS teams agrees on applying to the May Deadline for the NIH R01 grant. Dr. Diller will send literature on the relationship between cell permeability and cell viability/cell stess/cell damage to Andrea and she will broadcast it to the group.
The remaining task for completing the control loop is to align the mesh that Jessica creates prior to treatment to the biological domain the day of treatment. This is an image registration problem and several methods are available as a solution including:
Dr. Bajaj has an in-house code setup for image registration. It is currently setup for 2D image registration and capable of registering translations, rotations. 2.
http://bishopw.loni.ucla.edu/AIR5 this website claims that they have a code to perform the image registration 3.
A simple code can be written using existing data structures that will do an image registration ASSUMING ONLY rigid body rotation and translation.
However, the first order of business is to obtain a data set from MDA from which we can test the image registration code.
February is the next scheduled laser treatment of a canine at MDA. Testing of every aspect (automatic data transfer, filtering, computations, visualization) of the DDDAS code is scheduled for the month of January. The code must be tested on a simulated control loop environment and must demonstrate reliability during both the simulated laser treatment as well as phantoms runs on agar and ex vivo tissue before being considered for use on a living subject.